Isolation vs The Substance
The Substance has the higher audience score (7.2/10 against 5.5/10 for Isolation). Isolation is the shorter watch at 1h 35m compared with 2h 21m. Isolation is the older of the two (2005 against 2024). Both are horror, science fiction movies, so they suit a similar mood.
Isolation
The Substance| Isolation | The Substance | |
|---|---|---|
| Audience score | ★ 5.5/10 | ★ 7.2/10 |
| Year | 2005 | 2024 |
| Length | 1h 35m | 2h 21m |
| Genres | Horror, Science Fiction | Drama, Horror, Science Fiction |
| Country | – | – |
| Director | Billy O'Brien | Coralie Fargeat |
| Main cast | Sean Harris, Ruth Negga, Stanley Townsend, Essie Davis, John Lynch | Hugo Diego Garcia, Demi Moore, Oscar Lesage, Dennis Quaid, Margaret Qualley |
Synopsis
Isolation
On a remote Irish farm, five people become unwilling participants in an experiment that goes nightmarishly wrong.
The Substance
A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
Where to watch
Where to watch IsolationWhere to watch The Substance
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